![]() ![]() HRQoL end points were measured using the European Organisation for the Research and Treatment of Cancer Core (EORTC) Quality of Life Questionnaire (QLQ-C30), EQ-5D visual analog rating scale (VAS), and Functional Assessment of Cancer Therapy Kidney Cancer Symptom Index-Disease-Related Symptoms (FKSI-DRS) questionnaires.īetter or not different overall improvement rates from baseline between pembrolizumab + axitinib and sunitinib were observed for the FKSI-DRS (-0.79% improvement vs sunitinib 95% confidence interval -7.2 to 5.6), QLQ-C30 (7.5% improvement vs sunitinib 95% CI 1.0-14), and EQ-5D VAS (9.9% improvement vs sunitinib 95% CI 3.2-17). Outcome measurements and statistical analysis: HRQoL data were available for 429 patients treated with pembrolizumab + axitinib and 423 patients treated with sunitinib. To evaluate health-related quality of life (HRQoL) in KEYNOTE-426.Ī total of 861 patients were randomly assigned to receive pembrolizumab + axitinib (n = 432) or sunitinib (n = 429). In the phase 3 KEYNOTE-426 ( NCT02853331) trial, pembrolizumab + axitinib demonstrated improvement in overall survival, progression-free survival, and objective response rate over sunitinib monotherapy for advanced renal cell carcinoma (RCC). 19 Barts Health and the Royal Free NHS Trusts, Barts Cancer Institute, London, UK Queen Mary University of London, London, UK.18 Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA.15 Bell Land General Hospital, Osaka, Japan.14 Adelaide and Meath Hospital, University College Dublin, Dublin, Ireland.13 Centre Antoine Lacassagne, Université Côte d'Azur, Nice, France.12 Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.11 Sumy State University, Sumy Regional Oncology Center, Sumy, Ukraine.10 Palacký University Olomouc, Medical School and Teaching Hospital, Olomouc, Czech Republic. ![]() 9 Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.8 CHU de Québec and Université Laval, Quebec City, QC, Canada.7 Central Clinical Hospital With Outpatient Clinic, Moscow, Russia.6 The Christie NHS Foundation Trust, Manchester, UK.5 Russian Scientific Center of Roentgen Radiology, Moscow, Russia.4 Dnipro State Medical University, Dnipro, Ukraine.3 Fox Chase Cancer Center, Philadelphia, PA, USA.Electronic address: 2 Vanderbilt University Medical Center, Nashville, TN, USA. 1 Department of Urology, Eberhard Karls University of Tübingen, Tübingen, Germany. ![]()
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